林幸榮教授 Shing-Jong Lin, M.D., Ph.D., F.A.C.C.

  • 信箱

  • 電話

    +886 - 2 - 28712121 / ext. 7578

  • 個人連結

  • 職位

    現職: 臺北榮民總醫院內科部心臟科特約醫師 臺北醫學大學 董事 台灣高血壓學會 副理事長 教職: 國立陽明大學 臨床醫學研究所教授

  • 學經歷

    臺北醫學大學醫學系醫學士、美國哥倫比亞大學醫學博士

經      歷  :

  臺北榮民總醫院 內科部住院醫師 (1979/06~1984/06)
  臺北榮民總醫院 心臟內科主治醫師 (1984/07~)
  臺北榮民總醫院 心臟內科主任 (2004/01~2009/05)
  臺北榮民總醫院 教學研究部主任 (2009/05~2013/10)
  臺北榮民總醫院 醫學研究部主任 (2013/11~2017/07)
  臺北榮民總醫院 健康管理中心主任 (2017/07~2020/01)
  國立陽明大學 臨床醫學研究所所長 (1998/08~2004/07)
  國立陽明大學 醫學院副院長 (2009/08~2011/01)
  國立陽明大學 醫學院代理院長 (2011/02~2011/07)
  國立陽明大學 研究發展處研發長 (2011/08~2015/07)
  國立陽明大學 心臟血管研究中心主任 (2005/08~2017/02) 
  中華民國心臟學會 理事長 (2012/05~2014/05)
  亞太心臟學會 副會長 (2015/05~2017/07)
   
專長學科:
  成人心臟內科, 心導管檢查 Cardiac Catheterization
  經皮氣球擴張血管成形術及支架 PTCA + stent
  國內、外醫學雜誌編輯、審稿,國際醫學會議主辦、主持和演講
  分子生物學教學、研究, 血管支架材質研發,動脈硬化 Atherosclerosis、冠狀動脈疾病、
  血脂異常 Hyperlipidemia、高血壓 Hypertension、冠狀動脈心臟病的分子遺傳研究
  研究生碩、博士論文指導
   
專科證書:
  中華民國內科專科醫師
  中華民國心臟專科醫師
  介入性心臟專科醫師
  重症醫學專科醫師
   
專科學會:
  中華民國內科醫學會
  中華民國心臟學會
  中華民國重症醫學會
   
  1. Ting CT, Brin KP, Lin SJ, Wang SP, Chang MS, Chiang BN, Yin FCP. Arterial hemodynamics in human hypertension. J Clin Invest 1986;78:1462-1471.
  2. Lin SJ, Jan KM, Weinbaum S, Chien S. Transendothelial transport of low density lipoprotein in association with cell mitosis in rat aorta. Arterioscler (Thromb Vasc Biol)1989;9:230-236.
  3. Lin SJ, Jan KM, Chien S. The role of dying endothelial cells in transendothelial macromolecular transport. Arterioscler (Thromb Vasc Biol) 1990;10:703-709.
  4. Lin SJ, Hong CY, Chang MS, Chiang BN, Chien, S. Increased aortic endothelial cell death and enhanced transendothelial macromolecular transport in streptozotocin-diabetic rats. Diabetologia 1993;36:926-930.
  5. Chen YH, Chen YL, Lin SJ*, Chou CY, Mar GY, Chang MS, Wang SP. Electron microscopic studies of phenotypic modulation of smooth muscle cells in coronary arteries of patients with unstable angina pectoris and postangioplasty restenosis.Circulation 1997;95:1169-1175.
  6. Feng AN, Chen YL, Chen YT, Ding YZ, Lin SJ*. Red wine inhibits MCP-1 expression and modestly reduces neointimal hyperplasia following balloon injury in cholesterol-fed rabbits. Circulation 1999;100:2254-2259.
  7. Chen YH, Chau LY, Lin MW, Chen LC, Yo MH, Chen JW, Lin SJ*. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with angiographic restenosis after coronary stenting. Eur Heart J 2004;25:39-47.
  8. Lin SJ, Shyue SK, Liu PL, Chen YH, Ku HH, Chen JW, Tam KB, Chen YL. Adenovirus-mediated overexpression of catalase attenuates oxLDL-induced apoptosis in humen aortic endothelial cells via AP-1 and C-jun N-terminal kinase/extracellular signal-regulated kinase mitogen-activated protein kinase pathways. J Mol Cell Cardiol2004;36:129-39.
  9. Lin SJ, Shyue SK, Hung YY, Chen YH, Ku HH, Chen JW, Tam KB, Chen YL. Superoxide dismutase inhibits the expression of VCAM-1 and ICAM-1 induced by TNFα in human endothelial cells via the JNK/p38 pathways. Arterioscler Thromb Vasc Biol2005;25: 334-340.
  10. Leu HB, Chen JW, Lin SJ. Circulating Endothelial Progenitor Cells. N Engl J Med2005;353:2613-2616.
  11. Shih CM, Lin SJ*, Su YY, Shih CC. Amorphous oxide—a platform for drug delivery. J Control Release 2005;102:539-549.
  12. Huang PH, Chen LC, Leu HS, Ding YA, Chen JW, Wu TC, Lin SJ*. Enhanced coronary calcification determined by electron beam computed tomography is strongly related to endothelial dysfunction in patients with suspected coronary artery disease. Chest2005;128: 810-815.
  13. Lin FY, Chen YH, Tsai JS, Chen JW, Yang TL, Wang SJ, Li CY, Chen YL, Lin SJ*. Endotoxin induces Toll-like receptor 4 expression in vascular smooth muscle cells via NADPH oxidase activation and mitogen-activated protein kinase signaling pathways.Arterioscler Thromb Vasc Biol 2006;26:2630-2637.
  14. Lin FY, Chen YH, Lin YW, Tsai JS, Chen JW, Chen YL, Li CY, Lin SJ*. The role of human antigen R, an RNA-binding protein, in mediating the stabilization of Toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation. Arterioscler Thromb Vasc Biol 2006;26:2622-2629.
  15. Lin SJ, Shyue SK, Shih MC, Chu TH, Chen YH, Ku HH, Chen JW, Tam KB, Chen YL. Superoxide dismutase and catalase inhibit oxidized low-density lipoprotein-induced human aortic smooth muscle cell proliferation: Role of cell-cycle regulation, mitogen-activated protein kinases, and transcription factors. Atherosclerosis 2007;190:124-134.
  16. Huang PH, Chen YH, Chen YL, Wu TC, Chen JW, Lin SJ*. Vascular endothelial function and circulating endothelial progenitor cells in patients with cardiac syndrome X. Heart 2007;93:1064-70.
  17. Wu TC, Chen YH, Leu HB, Chen YL, Lin FY, Lin SJ*, Chen JW. Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis. Free Radic Biol Med 2007;43:1508-1522.
  18. Chen YH, Chau LY, Chen CW, Lin SJ*. Serum Bilirubin and Ferritin Levels Link Between Heme Oxygenase-1 Gene Promoter Polymorphism and Susceptibility to Coronary Artery Disease in Diabetic Patients. Diabetes Care 2008;31:1615-1620.
  19. Wang SH, Lin SJ, Chen YH, Lin FY, Shih JC, Wu CC, Wu HL, Chen YL. Late outgrowth endothelial cells derived from Wharton’s jelly in human umbilical cord reduce neointimal formation after vascular injury: involvement of pigment epithelium-derived factor.Arterioscler Thromb Vasc Biol 2009;816-22.
  20. Huang PH, Chen YH, Wang CH, Chen JS, Tsai HY, Lin FY, Lo WY, Wu TC, Sata M, Chen JW, Lin SJ.* Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelialprogenitor cells. Arterioscler Thromb Vasc Biol 2009;1179-84.
  21. Huang PH, Chen YH, Tsai HY, Chen JS, Wu TC, Lin FY, Sata M, Chen JW, Lin SJ.* Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability.Arterioscler Thromb Vasc Biol 2010;30:869-77.
  22. Huang PH, Huang SS, Chen YH, Lin CP, Chiang KH, Chen JS, Tsai HY, Lin FY, Chen JW, Lin SJ.* Increased circulating CD31+/annexin V+ apoptotic microparticles and decreased circulating endothelial progenitor cell levels in hypertensive patients with microalbuminuria. J Hypertens 2010;28:1655-65.
限於篇幅,以上謹為代表著作 
  陳萬裕教授學術基金會優秀論文獎 1989
   
  臺北榮民總醫院優秀論文獎 1990
   
  歐洲心臟學會Fellow, European Society of Cardiology 1990
   
  中華民國心臟學會丁農獎 1991
   
  臺北榮民總醫院優秀論文獎 1991
   
  中華民國心臟學會優秀論文獎 1992
   
  美國心臟學院院士Fellow, American College of Cardiology 1992
   
  臺北榮民總醫院醫師學術論文獎 1993
   
  Uchida International Award 日本循環器學研究振興財團國際研究獎 1993
   
  中華醫學研究獎助基金會優秀論文獎 1997
   
  中華民國血脂及動脈硬化學會〝姜必寧教授學術成就獎〞 1998
   
  嚴慶齡醫學基金會第二期五年研究成果第一名 1999
   
  多次國科會研究獎 1990~2001
   
  第四屆榮清陽合作研究計劃優良論文第一名 2004
   
  Allan B. Dove Memorial Medal Award, 2005, the Wire Association International
   
  國立陽明大學教師學術卓越獎勵 2007-2008
   
  英國專利 GB24228252 Yea-Yang Su, Chun-Che Shin, Chun-Ming Shin, Shing-Jong Lin Amorphous oxide surface film for metallic implantable devices and method for production thereof. 2008
   
  臺北榮民總醫院五十週年院慶(重大學術成就)獎 2008
   
  國立陽明大學教師學術卓越獎勵 2009-2010